We are interested in mechanisms underlying the formation and regulation of inhibitory synapses in the central nervous system. We study these mechanisms by combining electrophysiological methods with vital imaging and molecular biology techniques. Experiments on slice preparations and cultures of the developing retina, superior colliculus and visual cortex allowed us to explore the limits of synaptic transmission at individual GABAergic contacts formed under a variety of defined growth conditions. Recently we somewhat shifted our research interests to pathophysiological mechanisms associated with Huntington's and Parkinson's disease focussing on the origin of depressed synaptic inhibition.