Publications/PubMed Articles



List of publications 1999 - 2017

• links to publications at the end of each entry

Dvorzhak A, Melnick I, Grantyn R. Astrocytes and presynaptic plasticity in the striatum: Evidence and unanswered questions. Brain Res Bull. (2017) S0361-9230

Vagner T, Dvorzhak A, Wójtowicz AM, Harms C, Grantyn R. Systemic application of AAV vectors targeting GFAP-expressing astrocytes in Z-Q175-KI Huntington's disease mice. Mol Cell Neurosci. (2016) 1044-7431

Dvorzhak A, Vagner T, Kirmse K, Grantyn R. Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice. J Neurosci. (2016) 4959-75

Rothe T, Deliano M, Wójtowicz AM, Dvorzhak A, Harnack D, Paul S, Vagner T, Melnick I, Stark H, Grantyn R. Pathological gamma oscillations, impaired dopamine release, synapse loss and reduced dynamic range of unitary glutamatergic synaptic transmission in the striatum of hypokinetic Q175 Huntington mice. Neuroscience. (2015) 311:519-38

Dvorzhak A, Gertler C, Harnack D, Grantyn R. High frequency stimulation of the subthalamic nucleus leads to presynaptic GABA(B)-dependent depression of subthalamo-nigral afferents. PLoS One. (2013) 8:e82191

Wójtowicz AM, Dvorzhak A, Semtner M, Grantyn R. Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3. Front Neural Circuits. (2013) 7:188

Dvorzhak A, Semtner M, Faber DS, Grantyn R. Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin. J Physiol (2013) 591:1145-66

Grantyn R, Henneberger C, Jüttner R, Meier JC, Kirischuk S. Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins.
Front.Cell.Neurosci (2011) 5:13

Grantyn R and Kirischuk S. Neurotransmitter Release: Synchronous and Asynchronous. In: Squire LR (ed.) Encyclopedia of Neuroscience (2009) 6: 1067-1071

Kirmse K, Kirischuk S, Grantyn R. Role of GABA transporter 3 in GABAergic synaptic transmission at striatal output neurons. Synapse (2009) 63:921-929

Höltje M, Djalali S, Hofmann F, Münster-Wandowski A, Hendrix S, Boato F, Dreger SC, Große G, Henneberger C, Grantyn R, Just I, Ahnert-Hilger G. A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J (2009) 23:1115-26

Kirmse K, Dvorzhak A, Kirischuk S, Grantyn R. GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum. J Physiol (2008) 586:5665-5678

Eichler SA, Kirischuk S, Jüttner R, Schäfermeier PK, Legendre P, Lehmann TN, Gloveli T, Grantyn R, Meier JC. Glycinergic tonic inhibition of hippocampal neurons with depolarising GABAergic transmission elicits histopathological signs of temporal lobe epilepsy. J Cell Mol Med (2008) 12:2848-2866

Kirmse K, Dvorzhak A, Grantyn R, Kirischuk S. Developmental downregulation of excitatory GABAergic transmission in neocortical layer I via presynaptic adenosine A1 receptors. Cereb Cortex (2008) 18:424-432

Kirmse K, Dvorzhak A, Henneberger C, Grantyn R, Kirischuk S.
Cajal Retzius cells in the mouse neocortex receive two types of pre- and postsynaptically distinct GABAergic inputs. J Physiol (2007) 585:881-895

Henneberger C, Redman SJ, Grantyn R. Cortical efferent control of subcortical sensory neurons by synaptic disinhibition. Cereb Cortex (2007) 17:2039-49

Salama-Cohen P, Arevalo MA, Grantyn R, Rodriguez-Tebar A. Notch and NGF/p75NTR control dendrite morphology and the balance of excitatory/inhibitory synaptic input to hippocampal neurones through Neurogenin 3. J Neurochem.(2006) 97:1269-78

Singh B, Henneberger C, Betances D, Arevalo MA, Rodriguez-Tebar A, Meier JC, Grantyn R. Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons. J Neurosci (2006) 26:7189-200

Henneberger C, Kirischuk S, Grantyn R. Brain-derived neurotrophic factor modulates GABAergic synaptic transmission by enhancing presynaptic glutamic acid decarboxylase 65 levels, promoting asynchronous release and reducing the number of activated postsynaptic receptors. Neurosci (2005) 135:749-763

Kirmse K, Grantyn R, Kirischuk S. Developmental downregulation of low-voltage-activated Ca2+ channels in Cajal-Retzius cells of the mouse visual cortex. Eur J Neurosci (2005) 21:3269-76

Meier JC, Henneberger C, Melnick I, Racca C, Harvey RJ, Heinemann U, Schmieden V, Grantyn R. RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency. Nat Neurosci (2005) 8:736-744

Jüttner R , Moré MI , Das D, Babich A, Meier J, Henning M, Erdmann B, Müller EC, Otto A, Grantyn R, Rathjen FG. Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. Neuron (2005) 46:233-245

Henneberger C, Jüttner R, Schmidt SA, Walter J, Meier JC, Rothe T, Grantyn R. GluR- and TrkB-mediated maturation of GABA receptor function during the period of eye opening. Eur J Neurosci (2005) 21:431-440

Kirischuk S, Juttner R, Grantyn R. Time-matched pre- and postsynaptic changes of GABAergic synaptic transmission in the developing mouse superior colliculus. J Physiol (2005) 563:795-807

Djalali S, Holtje M, Grosse G, Rothe T, Stroh T, Grosse J, Deng DR, Hellweg R, Grantyn R, Hortnagl H, Ahnert-Hilger G. Effects of brain-derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development. J Neurochem (2005) 92:616-627

Salama-Cohen P, Arevalo MA, Meier J, Grantyn R, Rodriguez-Tebar A. NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch. Mol Biol Cell (2005) 16:339-347

Meier J, Grantyn R. Preferential accumulation of GABAA receptor {gamma}2L, not {gamma}2S cytoplasmic loops at spinal cord inhibitory synapses. J Physiol (2004) 559:355-365

Meier J, Grantyn R. A gephyrin-related mechanism prohibiting glycine receptor anchoring at GABAergic synapses. J Neurosci (2004) 24:1398-1405

Grantyn R, Jüttner R, Meier J. (2003) Development and use-dependent modification of synaptic connections in the visual layers of the rodent superior colliculus. In: The superior Colliculus (Hall WC, Moschovakis A, eds), CRC Press, pp 173-210.

Meier J, Akyeli J, Kirischuk S, Grantyn R. GABA(A) receptor activity and PKC control inhibitory synaptogenesis in CNS tissue slices. Mol Cell Neurosci (2003) 23:600-613

Kirischuk S, Akyeli J, Iosub R, Grantyn R. Pre- and postsynaptic contribution of GABAC receptors to GABAergic synaptic transmission in rat collicular slices and cultures. Eur J Neurosci (2003) 18:752-758

Kirischuk S, Grantyn R.Intraterminal Ca2+ concentration and asynchronous transmitter release at single GABAergic boutons in rat collicular cultures. J Physiol (2003) 548:753-764

Meier J. The enigma of transmitter-selective receptor accumulation at developing inhibitory synapses. Cell Tissue Res (2003) 311:271-276

Meier J, Jüttner R, Kirischuk S, Grantyn R. Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity. Mol Cell Neurosci (2002) 21:324-340

Kirischuk S, Grantyn R. Inter-bouton variability of synaptic strength correlates with heterogeneity of presynaptic Ca(2+) signals. J Neurophysiol (2002) 88:2172-2176

Kirischuk S, Clements JD, Grantyn R. Presynaptic and postsynaptic mechanisms underlie paired pulse depression at single GABAergic boutons. J Physiol (2002) 543:99-116

Henneberger C, Jüttner R, Rothe T, Grantyn R. Postsynaptic action of BDNF on GABAergic synaptic transmission in the superficial layers of the mouse superior colliculus. J Neurophysiol (2002) 88:595-603

Wagner N, Wagner KD, Schley G, Coupland SE, Heimann H, Grantyn R, Scholz H. The Wilms' tumor suppressor wt1 is associated with the differentiation of retinoblastoma cells. Cell Growth Differ (2002) 13:297-305

Jüttner R, Meier J, Grantyn R. Slow IPSC kinetics, low levels of alpha1 subunit expression and paired-pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus. Eur J Neurosci (2001) 13:2088-2098

Jüttner R, Henneberger C, Grantyn R, Rothe T. Early onset of glutamatergic and GABAergic synaptic activity in the visual layers of the rodent superior colliculus. Int J Dev Neurosci (2001) 19:255-261

Kirischuk S, Grantyn R. A readily releasable pool of single inhibitory boutons in culture. Neurorep (2000) 11:3709-3713

Henneberger C, Grantyn R, Rothe T. Rapid genotyping of newborn gene mutant mice. J Neurosci Meth (2000) 100:123-126

Wagner N, Wagner KD, Sefton M, Rodriguez TA, Grantyn R. An abnormal response of retinoblastoma cells (Y-79) to neurotrophins. Invest Ophthalmol Vis Sci (2000) 41:1932-1939

Kirischuk S, Veselovsky N, Grantyn R. Single-bouton-mediated synaptic transmission: postsynaptic conductance changes in their relationship with presynaptic calcium signals. Pflügers Arch (1999) 438:716-724

Rothe T, Bähring R, Carroll P, Grantyn R. Repetitive firing deficits and reduced sodium current density in retinal ganglion cells developing in the absence of BDNF. J Neurobiol (1999) 40:407-419

Kirischuk S, Veselovsky N, Grantyn R. Relationship between presynaptic calcium transients and postsynaptic currents at single gamma-aminobutyric acid (GABA)ergic boutons. Proc Natl Acad Sci U S A (1999) 96:7520- 7525

Taschenberger H, Juttner R, Grantyn R. Ca2+-permeable P2X receptor channels in cultured rat retinal ganglion cells. J Neurosci (1999) 19:3353-3366

Rothe T, Jüttner R, Bähring R, Grantyn R. Ion conductances related to development of repetitive firing in mouse retinal ganglion neurons in situ. J Neurobiol (1999) 38:191-206


PhD Theses, Habilitation

Akyeli J. Neurotrophinerge Wirkung auf die postnatale Umkehr der GABA-Wirkung. Dr. med. M.D. Thesis at the University Medicine – Charité (2007) 1-83.

Kirmse K. Die GABAerge synaptische Transmission auf Cajal-Retzius-Zellen des visuellen Kortex der Maus. M.D. Thesis at the University Medicine – Charité (2007) 1-22.

Meier, J.C. Molekulare Plastizität inhibitorischer Synapsen im ZNS. Habilitationsschrift at the University Medicine – Charité (2007) 1-60.

Walter J. Glutamaterge Modulation der GABAergen synaptischen Transmission durch metabotrope Glutamatrezeptoren der Gruppe I sowie deren Einfluss auf die Synaptogenese in Hirnschnittpräparaten. M.D. Thesis at the University Medicine – Charité (2006) 1-97.

Singh, B. Differential Regulation of glutamatergic and GABAergic synaptogenesis by BDNF and PRG1. Dr. rer. nat. thesis at the Free University in Berlin (2005) 1-115


Biographical Interviews